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Product details

File Size: 2399 KB

Print Length: 290 pages

Publisher: Basic Books; 1 edition (October 30, 2012)

Publication Date: October 30, 2012

Sold by: Hachette Book Group

Language: English

ASIN: B00918JR5Q

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Amazon Best Sellers Rank:

#214,984 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

This is an absolutely amazing book.For millennia, there has been a sense that living matter is somehow different from ordinary matter. There had to be some kind of vital force, something outside the well understood laws of physics and chemistry. For centuries, the challenge stood, even as scientists discovered cells, organic synthesis, genes and protein structure.Then science reached the nanoscale. In the late 1980s and early 1990s a new class of microscope opened up the world of the nanometer. Individual molecules could be viewed, first statically, then in motion. New techniques could mark individual molecules and tweezers made of light beams opened a new area to experimentation and measurement. At the nanoscale biology, chemistry and physics converge. Living creatures are made of tiny machines.These machines are made of molecules. They operate in a veritable storm of random motion and random collisions, and it is this storm that provides the energy for living motion - cellular motion, genetic manipulation and chemical transport. The second law of thermodynamics has this random motion effectively useless, unable to drive directed activity, but there is a loophole. Energy can be used to destroy information, to forget and reset molecular state. In cells, this energy is provided by ATP losing a phosphorous atom and converting to ADP. It seems insignificant, but at the nanoscale this minuscule jump burns at 7000 degrees. It is these fiery sparks of forgetfulness that drive life's ratchet and make life possible.This book is a biophysicists manifesto. There has been a critical convergence in our understanding of living systems. We can look at the mysterious vital force up close and understand it. We can go to Youtube and watch a myosin molecule walk its track, buffeted by the invisible storm. It's an amazing story, and this book does a wonderful job of bringing this story to anyone with even a basic scientific background. I cannot recommend this book highly enough. We truly live in amazing times.

Wants to know how life began and where organic chemistry becomes purposeful life. This is the book. When I was done, I put it down and said to myself "Well there you have it, now I know how it got this way" . I have spent the last 20 years reading every science book I could find to try to really understand what it is that I'm looking at every day, how the hell did this happen? Well now I know. I may never have to pick up another book again in my life. The author writes in such a pleasant way as to avoid any kind of condescending undercurrent, he knows some stuff would be impossible for guys like me to truly understand without a Phd. in molecular biology or some such discipline, so he does his best to make the incomprehensible engaging. I'd like to have a beer or 6 with this guy - oh, that's right I quit drinking a while back. Somehow, having a window into the line between organic chemistry and self perpetuating living things makes me feel, at long last, that the universe I have been pondering for the last 60 years does make sense, and that this line, like deep time and such concepts, can't be felt at a gut level. But it can be revealed, slowly, to guys like me over time.

This is a wonderful, highly enjoyable, and educational book that explains concepts that are often presented solely via non-transparent mathematical analyses. The author, Peter Hoffmann asks, "How can molecules create the “purposeful” action that characterizes cells and bacteria? How do we go from assemblies of mere atoms to the organized complex motions in a cell?" Hoffmann addresses these issues, explaining complex processes in understandable terms, and uses metaphors very effectively. I particularly enjoyed his explanation of Brownian ratchets using the metaphor of a mythical nanoscale version of Sisyphus pushing a boulder up a hill. Peter Hoffmann is a gifted writer, and this book is a gem that illuminates the physics and biology of life processes skillfully.

I really enjoyed this book. I read it back in 2012, but never seemed to get around to writing a review. It discusses how life takes advantage of physical law to function. Even in the modern world, many people seem to believe in a vital spirit that makes life metaphysically distinct from non-life. I read this alongside several other books to familiarize myself with some of the basics of biology. I was in college studying experimental psychology (with a focus on cognitive neuroscience) with a philosophy minor and was quite interested (and still am) in the debates in philosophy of mind over physicalism. I am a physicalist, so I wanted to really be familiar with some of the bare basics of how life works to make sure I wasn't on shaky grounds. Below are listed a couple other books I read alongside it that those who are interested in this book might also want to read:Wetware: A Computer in Every Living Cell (discusses how single celled organisms process information)What is Life? by Addy Pross (discusses the chemical principles by which life could emerge without getting much into specifics)The Machinery of Life by David S. GoodsellI didn't read it alongside this, but The Extended Phenotype by Richard Dawkins would probably be of interest.

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